A three-step route to a tricyclic steroid precursor.
نویسندگان
چکیده
2-Alkyl cyclohexenones are useful intermediates for organic synthesis. The Wittig reaction of a series of aldehydes with (cyclopropylmethyl)triphenylphosphonium bromide delivered the corresponding alkenyl cyclopropanes. UV irradiation in the presence of Fe(CO)5 converted the alkenyl cyclopropanes to the 2-substituted cyclohexenones. This approach enabled a three-step synthesis of the tricyclic core of estrone methyl ether.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 73 20 شماره
صفحات -
تاریخ انتشار 2008